This book is the reason I became a neuroscientist

books:


	• Stress, the Aging Brain, and the Mechanisms of Neuron Death (Bradford Books) Robert M. Sapolsky The MIT Press, 1992 - 441 pages average customer review:based on 1 review view larger image
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This book is the reason I became a neuroscientist

True. Though probably not for beginners, this book is probably good for anyone with alittle college experience in biology. Sapolsky writes in his normal clear, thoughtful style to explore the affects of stress on the brain. The ability of this book to describe a scientific problem and then explore the experiments and the analysis of experiments to come up with a hypothesis demonstrates the artistry and passion which underlies the scientific experience.

Honorable Mention in the category of Biological Sciences, 1992 Professional/Scholarly Publishing Annual Awards Competition presented by the Association of American Publishers, Inc.

Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related hormones can also endanger the brain. Strategies to reduce stress and methods to protect neurons from further damage are proposed, and the relevance for humans of the animal research findings are clearly delineated.

Sapolsky provides an extensive review of the recent, exciting data on glucocorticoids, the adrenal steroid hormones (hydrocortisone or cortisol in humans) that are released during stress. Excessive exposure to these hormones can damage the brain and make neurons more vulnerable to neurological insults. The findings he reports and ideas he synthesizes may have profound implications for understanding brain aging and resistance of the brain to the damaging effects of strokes, seizures, and possibly Alzheimer's disease.

In part I Sapolsky focuses on how the failure of glucocorticoid regulation and subsequent excessive secretion combine to cause a complex cascade of degeneration in the brain during aging. In part 11 he addresses the implications of glucocorticoid neurotoxicity for neurology. Each chapter includes a helpful summary of the major points discussed as well as a capsule review of information from the previous chapters.

Robert M. Sapolsky is Associate Professor of Biology and Neuroscience at Stanford University. He is also Research Associate at the Institute for Primate Research, National Museums of Kenya, Nairobi, and a MacArthur Fellow.

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