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Protective Groups in Organic Synthesis
Theodora W. Greene, Peter G. M. Wuts

Wiley-Interscience, 1999 - 779 pages

average customer review:based on 11 reviews
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   highly recommended  highly recommended





must have

if you are synthetic chemist you ought to have this book with you


glad i bought it

i'm do organic synthesis. i reference this one once a week on average. it's the first stop whenever a protecting group questions comes up.









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The Book Will be Your Bible in Lab

If you doing any sort of organic chemistry in the lab, you will really get your hands into this handy reference on protecting groups. The book neatly organized into functional groups and their protecting groups. A Primer for organic chemists. It will save you zillion hours of researching for papers/references on the appropriate protecting groups used in reactions.


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A must have for any synthetic laboratory

There are other protecting group books out there but I found this one to be the most comprehensive and easy to use.


Protecting my thesis

This book contains methods for the installation and removal of practically every protecting group you can think of, and likely some you've never encountered. Most methods are referenced to articles containing representative procedures, saving valuable time scouring the literature. It is compact, well-organized and reasonably priced. Along with March's Advanced Organic Chemistry, this book is a must have for any organic chemist.


reviews: page 1, 2, 3



From the reviews of the previous editions:
* "For completeness, the authors . . . include protective groups and techniques for formation and cleavage that are seldom used as well as those that are more common. . . . Anyone who does organic synthesis must have convenient access to this book." -Journal of the American Chemical Society.
* "Essential to the modern synthetic organic chemist . . . should be in the libraries of all academic, governmental, and industrial organizations concerned with organic synthesis." -Polymer News.

Reflecting the latest advances in protective group methodology, this Third Edition of the proven laboratory reference is expanded by more than 50%, providing readers with a comprehensive compendium of 1,050 of the most useful protective groups as well as 5,350 references to original publications. Protective groups are organized by six major organic functional groups: hydroxyl, amino, carboxyl, carbonyl, sulfhydryl, and phosphate groups (the last new to this edition). Also added in this edition are protection of the alkyne-CH, expanded coverage of protection of all groups, and many new enzymatic methods of protection and deprotection. Each chapter briefly describes the classes of available protective groups, followed by an in-depth look at the chemistry of individual protective groups, their properties, and the best methods of formation and cleavage. Ten reactivity charts with more than 28,000 entries summarize the relative reactivities of 270 commonly used protective groups with 108 reagents. This book will be an indispensable reference for synthetic chemists and students.


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