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A Commotion in the Blood: Life, Death, and the Immune System (The Sloan Technology Series)
Stephen S. Hall

Holt Paperbacks, 1998 - 500 pages

average customer review:based on 11 reviews
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   highly recommended  highly recommended



excellent but bothersome

This is well-written and generally solid, but has a couple of flaws. The biggest is that the author seems to have been taken in by some researchersd who most likely were sources. The result: the book gives far too much credence to the work of an early 20th century doctor named Coley, whose family has funded research since and has campaigned for credit. Coley's work, while creative and provocative-- for which he deserves credit-- was not good science, and the book made it sound as if it was true. This troubled me throughout my reading. The writer also seems to take some pretty hard (and unfair) shots at a prominent current researcher, Steve Rosenberg. Again, the author was most likely listening too closely to a couple of sources. Rosenberg is far more likely to win a Nobel Prize than to fade into nothingness, as the author implies. He was the first person to stimulate the immune system to cure certain cancers. Nonetheless, this is a first-rate book, and if I didn't know anything about the subject (which I do) I would have enjoyed it even more than I did even including the flaws.


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a romp through tumor immunology

This is an engaging read! An excellent introduction for the reader curious about the history of cancer biology/immunology especially from the standpoint of clinical therapies. It also provides a glimpse of the inside workings of research institutes and scientific collaborations. The only reservation I have is that the prose tends to the purple but that is not too great a distraction from the skillful storytelling. Read it!









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Immunotherapy for laypeople

It's a shame this great book is out of print.

It's not easy going for the layperson although it is certainly more accessible than a great deal of medical information. But it IS fascinating.

Early strategies of dealing with cancer by manipulating the immune system which were discovered and championed by Dr. Coley (with surprising success since even he wasn't sure exactly how they worked) were abandoned and forgotten when the new "radiation" model found more powerful supporters in the medical community, like Dr. Coley's boss, Dr. Ewing.

Years later we see a terrific toll in human suffering exacted by radiation and chemotherapy. Current stem cell research and other immunological researches all "stem" from Coley's early experiments. Hall writes about the scientists, operating alone or in teams, who have made huge strides in the world of immune system research and therapy protocols, many of which the average person has never heard about.

I learned an enormous amount about how the body works and about how the immune system develops. Yes, this information is very detailed and not always easy to grasp, but Hall does a terrific job in trying to make it understandable to the non-medical reader. So many times we laypeople are flummoxed by jargon.

Hall details what scientists have been doing in the world of immune research. Some familiar names pop up like Dr. Gallo and others prominent in AIDS research. And Hall does a great job in writing about the personalities, the conflicts and the politics of the medical world--it's not all science, which is daunting enough to us!

I can't speak highly enough of this book. I really know a lot more about how the body works after reading it and I'm encouraged for the future, if only the public will get behind supporting these brilliant and innovative thinkers.

I had cancer which is one of the things that interested me in this book. As challenging as the book is, I could NOT put it down. It makes for interesting speculation about how our world would have developed if cancer protocols had gone in a different direction.


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Accessible to all

I thoroughly enjoyed Hall's account of the development of immunotherapy. I read it cover to cover. You need not be an immunologist to enjoy this book, but you might want to become one after.


The Future in Cancer Treatment

Stephen Hall does a marvelous job of giving an entertaining and understandable history of discoveries regarding the immune system and its role in cancer. Going well beyond the science, he introduces the men and women who forged through ridicule and adversity in a way that makes you know them as real people. I love this book! Hall is a great wordsmith. Look up Arthur Schopenhauer, you'll see his axioms of ridicule, adversity, and acceptance in the history presented. If you have cancer buy this book! It may change your life.
Richard R. Mason MS, DO, NMD


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reviews: page 1, 2, 3



A New York Times Notable Book, 1997
Library Journal, Best Book of 1997

Beginning with the "occasional miracles" of a mysterious turn-of-the-century cancer vaccine called Coley's toxins, Stephen S. Hall traces the story of how doctors have learned to harness the immune system and its "commotions" to develop a wide array of cutting-edge therapies. Moving deftly between laboratory and bedside, Hall's absorbing narrative navigates the politics of discovery and elucidates the dazzling complexities of the microscope slide, tracking the curiously potent cells and molecules at the heart of the immune response. From the author of "the best book written about the new age of biology" (Nobel laureate Philip Sharp), who "succeeds marvelously in making science accessible to the general reader," (New York Times), this fast-paced account of medicine in the making is part of the Sloan Foundation Technology Book series.



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