The book is organized into four sections, each preceded by a brief introduction explaining the order of the essays and their internal logic.
Part One deals with methodology, evaluates the theological interpretation of scientific theories, and proposes a program for a "theology of science."
Part Two looks at the interaction of science and religion from a historical perspective. Topics include the evolution of ideas connected with the place of man in the Universe and the evolution of matter, among others.
Part Three concentrates on the "creation and science" quandary, including the Big Bang theory and the role of probability and chance in science, as well as their impact on theological questions.
Part Four looks for vestiges of transcendence in contemporary science. Creative Tension joins the Templeton library of resources contributing to the growing global dialogue on science and religion.